What Is The Significance Of DMPK In Drug Development
Drug metabolism and pharmacokinetics (DMPK) is imperative for the safety evaluation of a new drug. Suboptimal DMPK studies can be responsible for the failure of new drugs in the clinical trial phases. The identification of applicable DMPK studies is necessary for the de-risking of candidate pharmaceutical molecules. DMPK studies can help in the optimization of compounds for the evaluation of drug-drug interactions, bioavailability, and related risks of the drug. The accurate assessment of DMPK profiles can minimize the attrition rate of the drug molecules and increase the efficacy of drug discovery. What DMPK services do you need during drug development? A DMPK study can shed light on the understanding of dosage, route of administration, toxicity level, PK/PD interactions, and other PK parameters. Standard DMPK studies at reputed laboratories utilize between two and four animal doses for testing a generic formulation. DMPK studies are necessary throughout the phases of
